Abstract:Using a novel gene expression system, we demonstrated the use of a minimal expression system in ain vivoin vivo gene expression experiment. We developed a minimal expression system in the mouse to study the effects of doxycycline on the expression of a regulatory gene in thereporter ofinduciblesystem,tissue specificluciferase. The expression ofluciferase was increased by doxycycline in a dose-dependent manner.luciferase was inhibited by doxycycline in a dose-dependent manner. The inducible expression ofluciferase was inhibited by doxycycline in a dose-dependent manner in a dose-independent manner. In vitro studies showed thatluciferase could be induced in a dose-dependent manner by doxycycline.
Citation:Kang Y, Zhang Y, Huang H, Li Y, et al. (2021) The inducible expression of regulatory proteins in mousereporterluciferase and its mechanism. PLoS ONE 15(1): e853504. https://doi.org/10.1371/journal.pone.00853504
Editor:Marianne M. Roos, University of Pennsylvania, Philadelphia, United States of America
Received:January 12, 2023;Accepted:October 22, 2023;Published:November 28, 2023
Copyright:© 2021 Kang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding:This work was supported by the National Institute of Health (T32-1-0263; T32-1-0263), the National Institutes of Health (NIH) National Institute of Child Health and Human Development (NIH NIDHD N01CA0163300), and the National Institute of General Medical Sciences (NIGMS). K. Y. was supported by the National Institutes of Health Postdoctoral Fellowships (NHI N00MD018087). S. H. and Z. are members of the Department of Education, National Institutes of Health (NIH) End-User Research Team (EURTA) and the University of Pennsylvania. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests:The authors have declared that no competing interests exist.
Active Ingredients:Each tablet contains 100mg of doxycycline (as doxycycline monohydrate).
Manufacturer:Dechra Veterinary Products
Prescription medicine:This is a prescription medicine. Please ensure that you have read the"Ordering Prescription Medicine"page before ordering this item. We require you to upload your veterinary prescription and post us the original. You will need to send your prescription to
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Commonly asked questions about Doxy Tablets:
What are Doxy Tablets?
Doxy is a semi-synthetic tetracycline antibiotic prescribed to treat various bacterial infections. Doxy prevents bacteria from reproducing so the animal’s immune system can fight the existing infection.
Why do cats and dogs use Doxy?
Doxy may be prescribed to treat various bacterial infections such as urinary tract and bladder infections.
What else should I know about Doxy?
Effective treatment for bacterial infections in dogs and cats. It is important to give Doxy with food.
What problems could my dog or cat have with Doxy?
Doxy may upset the stomach. Do not give multivitamins, calcium supplements, antacids, or laxatives within 2 hours of giving Doxy. These could lessen the effectiveness of the Doxy. Doxy may make your cat or dog's skin more sensitive to sunlight. Watch for reddening or burning of the skin, especially in hairless areas such as the nose, eyelids, or ears.
How do you use Doxy?
Doxy should be given with a moist treat or a small amount of liquid to make sure that the medication reaches the stomach. This is especially important for cats. Doxy can cause ulcers in the throat or oesophagus if it gets stuck before reaching the stomach. Always give the medication as your veterinarian directs.
What is in Doxy?
The active ingredient in Doxy is Doxycycline. Doxycycline is a tetracycline antibiotic. Tetracycline antibiotics prevent the growth and spread of certain types of bacteria.
US demand for tetracycline against resistant bacteriaAs a general rule, Doxy is a preferred treatment for cats and dogs due to its efficacy and safety profile.
Doxy should not be used by cats or dogs as a treatment for bacterial infections. Use only as directed.
Keep the tablets out of the sun. Also avoid direct sunlight. Avoid contact with the scalp, especially during the middle of the month ofnu and after the excretion factor is reduced.
Doxycycline can protect against sexually transmitted infections and should be used with caution. Most documented cases are thereforeAvoid contact with the tablets during the first 6 months of treatment.
If you are unable to give the Doxy due to too little alcohol or because of an under-prescribed amount of time, talk to your veterinarian.
Prelude to antibiotic resistance and effectiveness of tetracyclines
Doxy has been a reliable option for people due to its effectiveness in treating a variety of bacterial infections such as bacterial vaginosis, bacterial brain abscess, bacterial trachoma, pyodermagroup cerebralifi seizures, chlamydia trachoma, chlamydia trachomatis, gonorrhea, and cervicitis.
Effective treatment for bacterial infections in men and women and pyodermainflammation and inflammation.
DOXYCYCLINE (TORQUE) CAPSULE contains Doxycycline which belongs to group of medicines called Antibiotics. It is used for the management of various bacterial infections like that of chest, lung or nose (Ex. bronchitis, pneumonia, sinusitis), urinary tract (Ex. cystitis, urethritis), skin (Ex. acne), eyes or sexually transmitted diseases (Ex. gonorrhoea, syphilis, chlamydia).
DOXYCYCLINE (TORQUE) CAPSULE is also used to manage fevers associated with louse or tick bites and malaria (when chloroquine is ineffective). DOXYCYCLINE (TORQUE) CAPSULE can also be used to manage certain infections like scrub typhus (a disease carried by small insects), Rocky Mountain spotted fever, travellers’ diarrhoea, malaria and leptospirosis.
Avoid consumption of alcohol during management with DOXYCYCLINE (TORQUE) CAPSULE, as it may reduce the efficacy of this medicine. Before taking DOXYCYCLINE (TORQUE) CAPSULE, inform your doctor if you have myasthenia gravis, systemic lupus erythematosus, liver or kidney problems, porphyria, diarrhea or suspected syphilis.
DOXYCYCLINE (TORQUE) CAPSULE is not recommended for use in women who are pregnant, planning to become pregnant or breast-feeding. DOXYCYCLINE (TORQUE) CAPSULE should be used in children (8 years of age or less) only if the potential benefits outweigh the risks.
You should avoid exposure to strong sunlight while taking DOXYCYCLINE (TORQUE) CAPSULE as your skin may be more sensitive to sunburn than normal. The most common side effects of taking DOXYCYCLINE (TORQUE) CAPSULE are nausea, vomiting, joint pain, skin rash, fever, headache, etc. Consult your doctor if any of the symptoms get worse with time.
You should know that DOXYCYCLINE (TORQUE) CAPSULE should be used with a doctor’s consent, as it has not been approved by FDA in clinical trials, It is not recommended for use in children and adults who have myasthenia gravis, systemic lupus erythematosus, liver or kidney problems, pregnant women and breast-feeding women.possible serious side effects of DOXYCYCLINE (TORQUE) CAPSULE One tablet per day. You should not expect to see side effects from taking this medicine even if you feel well.possible serious side effects of DOXYCYCLINE (TORQUE) CAPSULE Watch your pharmacist if you experience any unusual symptoms.Doxycycline is a tetracycline antibiotic. It is generally used for the short-term treatment of bacterial infections. However, it may also be used for other infections like acne, rosacea, fevers, mild to moderate HIV infection, osteoporosis and others. Prescription DOXYCYCLINE (TORQUE) CAPSULE has been used for treatment of various bacterial infections for many years. Consult your doctor if you have any questions regarding this medicine.
For further information and to learn more about possible side effects, please visit the FDA page.
Additionally consult your doctor before taking DOXYCYCLINE (TORQUE) CAPSULE.
Store at 15-30°C (30-50°F) away from moisture, heat and sunlight. Keep all medicines out of reach of children.
Yes, Doxycycline capsules can be effective in treating acne. They are commonly prescribed by healthcare professionals for moderate to severe acne cases. Doxycycline is an antibiotic that works by reducing inflammation and controlling the growth of bacteria associated with acne.
Doxycycline helps to improve acne symptoms by:
Reducing inflammation: Doxycycline has anti-inflammatory properties that can help reduce the redness, swelling, and tenderness associated with acne.
Controlling bacterial growth: Acne is often caused by the overgrowth of bacteria on the skin, particularly a type of bacteria called Propionibacterium acnes. Doxycycline works by inhibiting bacterial protein synthesis, thereby controlling the growth and spread of these bacteria.
Regulating oil production: Doxycycline can also help regulate sebum (oil) production in the skin, which is a contributing factor in the development of acne.
You should combine systemic antibiotics such as doxycycline or capsules (both contraindicated in pregnancy and children under 12 years of age) with an appropriate topical agent such as or or. You should ideally continue treatment for 3 months.
How to split a Doxycycline tabletIdeally-| Strip of tablet | | | | | | | | | | | | |
Proper use: Do not use Doxycycline if you are allergic to doxycycline or any of its ingredients. If you are taking systemic antibiotics, follow the directions on the label.
Missed dose: If you miss a dose, take it as soon as possible. If it is almost time for your next dose, do not double the dose to make up for the missed dose.
Overuse or added effect: Do not take Doxycycline if you feel dizzy, have had a allergic reaction to doxycycline, or to any other medication. Double the dose if any allergic reactions occur.
Doxycycline can lead to a variety of side effects in some people. These may include:
Broad-spectrum side effects: Doxycycline can cause a broad range of side effects in individuals who take it. These may include nausea, vomiting, stomach pain, and headache.
Severe side effects: If you notice any unusual symptoms while taking Doxycycline, contact your doctor immediately.
Rare side effects: If any of these rare side effects become severe or persistent, contact your doctor immediately: Doxycycline may cause more problems than it could reduce, including bone, stomach, and neurological effects.
You should promptly report any unusual symptoms to your doctor. Doxycycline may make your skin more sensitive to medication.
How Doxycycline works to improve acne controlAcne occurs due to many factors. You may need:
Minimizing acne symptoms: Doxycycline helps to treat moderate to severe acne, by reducing inflammation and controlling the growth of acne-causing bacteria.
Minimizing acne symptoms and reducing the production of oil and a substance in the skin that contributes to acne breakouts. Doxycycline works by inhibiting the production of oil and reducing the production of a substance that promotes the development of acne breakouts.
Doxycycline helps to regulate sebum (oil) production in the skin, which is a contributing factor in the development of acne.
Minimizing acne symptoms and reducing the production of oil and a substance in the skin that regulates bacterial growth. Doxycycline reduces sebum (oil) production in the skin, which is a contributing factor in the development of acne.
Minimizing acne symptoms and reducing the production of oil and a substance that regulates oil production. Minimizing acne symptoms and reducing the production of oil and a substance in the skin.
Regulating sebum (oil) production. Minimizing acne symptoms and reducing the production of oil and a substance that regulated oil production.
Doxycycline is a type of antibiotic that is used to treat bacterial infections. It is also known by its generic name tetracycline. Doxycycline belongs to a group of drugs called tetracycline antibiotics. Doxycycline works by stopping the growth of bacteria and thus relieving symptoms of acne.
Doxycycline is an antibiotic, and it is commonly prescribed for treating a variety of infections, including acne. Doxycycline works by inhibiting the growth of bacteria, effectively eradicating the infection. However, it can also be used in the treatment of sexually transmitted diseases, including chlamydia. The effectiveness of Doxycycline is mainly due to its broad-spectrum activity against many bacteria, including both gram-positive and gram-negative bacteria.
Doxycycline is a tetracycline antibiotic. It is primarily used for treating a variety of bacterial infections. Doxycycline is a broad-spectrum antibiotic, and it is effective against both gram-positive and gram-negative bacteria.
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